177481-87-7Relevant academic research and scientific papers
Synthesis of 6-/10-membered ring analogs of the dienediyne core of the neocarzinostatin chromophore by palladium(0)-mediated ring-closure reactions
Brickmann, Kay,Hambloch, Frank,Suffert, Jean,Brueckner, Reinhard
, p. 457 - 471 (2007/10/03)
A strategy for the synthesis of the benzo-annulated bicyclic dienediyne analogs 46 and 48 of the DNA-cleaving natural product neocarzinostatin chromophore was developed. 2-Formylcyclohexanone (9) was converted stereoselectively first into the mono(enol tr
