177481-88-8

Basic information

• Product Name: 1-(2-((trimethylsilyl)ethynyl)phenyl)prop-2-yn-1-ol
• Synonyms: 1-(2-((trimethylsilyl)ethynyl)phenyl)prop-2-yn-1-ol
• CAS NO: 177481-88-8
• Molecular Weight: 228.366
• Mol File: 177481-88-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(2-((trimethylsilyl)ethynyl)phenyl)prop-2-yn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-((trimethylsilyl)ethynyl)phenyl)prop-2-yn-1-ol(177481-88-8)
• EPA Substance Registry System: 1-(2-((trimethylsilyl)ethynyl)phenyl)prop-2-yn-1-ol(177481-88-8)

Safety Data

• Hazardous Substances Data: 177481-88-8(Hazardous Substances Data)

Upstream product

• 77123-58-1 2-[2-(trimethylsilyl)ethynyl]benzaldehyde 
• 4301-14-8 acetylenemagnesium bromide 
• 74-86-2 acetylene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 1066-54-2 trimethylsilylacetylene 
• 26260-02-6 2-iodobenzaldehyde 

Downstream Products

• 179129-10-3 Trifluoro-methanesulfonic acid 5-[4-hydroxy-4-(2-trimethylsilanylethynyl-phenyl)-but-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester 
• 177481-89-9 3-Methoxy-3-<2-<(trimethylsilyl)ethynyl>phenyl>-1-propyne 
• 255840-56-3 1-(2-ethynylphenyl)prop-2-yn-1-ol 
• 255840-57-4 1-ethynyl-2-(propa-1,2-dienyl)benzene 
• 179129-11-4 (Z)-<5-<4-(2-Ethynylphenyl)-4-hydroxy-2-butynylidene>-1-cyclopenten-1-yl> trifluoromethanesulfonate 
• 177482-15-4 (Z)-<2-<3-(2-Ethynylphenyl)-3-methoxy-1-propynyl>-2-cyclohexen-1-ylidene>methyl trifluoromethanesulfonate 
• 179129-12-5 Trifluoro-methanesulfonic acid 5-[4-(tert-butyl-dimethyl-silanyloxy)-4-(2-ethynyl-phenyl)-but-2-yn-(Z)-ylidene]-cyclopent-1-enyl ester 
• 177482-14-3 Trifluoro-methanesulfonic acid 2-[3-methoxy-3-(2-trimethylsilanylethynyl-phenyl)-prop-1-ynyl]-cyclohex-2-en-(Z)-ylidenemethyl ester 

Relevant articles and documents

An Unusual Conversion of 2-(Alkynonyl)Alkynylbenzenes to Isocoumarins by a Retro-Favorskii-like Degradation

We report the discovery of an anomalous reaction of 2-(alkynonyl)alkynylbenzenes under AgI catalysis for the selective formation of isocoumarins. This reaction is previously undocumented for 2-(alkynonyl)alkynylbenzenes in terms of the reaction mechanism and the product formed. Water (H2O18) labeling studies suggested a possible mechanistic pathway in which the initial formation of a pyrylium ion is followed by hydrative dealkynylation, that is, water incorporation and alkyne expulsion, similar to a retro-Favorskii reaction.

Gold-catalyzed Intermolecular Oxidations of 2-Ketonyl-1-ethynyl Benzenes with N-Hydoxyanilines to Yield 2-Aminoindenones via Gold Carbene Intermediates

Gold-catalyzed oxidations of 2-ketonyl-1-ethynyl benzenes with N-hydroxyanilines yield 2-aminoindenone derivatives efficiently. Experimental data suggests that this process involves an α-oxo gold carbene intermediate, generated from the attack of N-hydroxyaniline on furylgold carbene intermediate, rather than the typical attack of oxidants on π-alkynes.

Synthesis of 5-/10-membered ring analogues of the dienediyne core of neocarzinostatine chromophore by palladium(0)-mediated ring-closure reaction

The new dienediynes 5, 6, and 7 were synthesised from a monoprotected diyne and an already described bis(enol triflate) 4 derived from formylcyclopentanone. When 5 and 6 were subjected to nucleophilic attack by a thiol, cycloaromatisation occurred, and the phenanthrenes 23a and 23b were obtained in 30 and 42% yield, respectively. VCH Verlagsgesellschaft mbH, 1996.