177558-38-2Relevant academic research and scientific papers
Indolizine SPLA2inhibitors
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Page/Page column 52, (2010/11/30)
A class of novel indolizine-1-functional compounds and indolizine-3-functional compounds is disclosed together with the use of such indolizine compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock. The compounds are indolizine-1-acetamides, indolizine-1-acetic acid hydrazides, indolizine-1-glyoxylamides, indolizine-3-acetamides, indolizine-3-acetic acid hydraxides, and indolizine-3-glyoxylasides.
Potent inhibitors of secretory phospholipase A2: Synthesis and inhibitory activities of indolizine and indene derivatives
Hagishita, Sanji,Yamada, Masaaki,Shirahase, Kazuhiro,Okada, Toshihiko,Murakami, Yasushi,Ito, Yuji,Matsuura, Takaharu,Wada, Masaaki,Kato, Toshiyuki,Ueno, Masahiko,Chikazawa, Yukiko,Yamada, Katsutoshi,Ono, Takashi,Teshirogi, Isao,Ohtani, Mitsuaki
, p. 3636 - 3658 (2007/10/03)
Phospholipase A2 is an enzyme which hydrolyzes the sn-2 position of certain cellular phospholipids. The liberated lysophospholipid and arachidonic acid are precursors in the biosynthesis of various biologically active products. As human nonpancreatic sPLA2 is present in high levels in the blood of patients in several pathological conditions, the potent sPLA2 inhibitors have been suggested to be useful drugs. Here we describe the synthesis, structure-activity relationship, and inhibitory activities of indolizine and indene derivatives. 1-(Carbamoylmethyl)indolizine derivatives and 1-oxamoylindolizine derivatives exhibited very potent inhibitory activity. The former was unstable to air oxidation, but the latter exhibited an improvement both in stability and in potency. Some compounds approached the stoichiometric limit of the chromogenic assay.
