177560-75-7Relevant academic research and scientific papers
Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors
Carter, Jeffery S.,Rogier,Graneto, Matthew J.,Seibert, Karen,Koboldt, Carol M.,Zhang, Yan,Talley, John J.
, p. 1167 - 1170 (2007/10/03)
A series of novel sulfone substituted 4,5-diarylthiazoles have been synthesized and evaluated for their inhibition of the two isoforms of human cyclooxygenase (COX-1 and COX-2). This series displays exceptionally selective COX-2 inhibition.
Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents
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, (2008/06/13)
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a non-toxic therapeutically effective amount of a compound of Formula I. STR1 The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
