17758-38-2

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dimethylpyrimidin-4(3H)-one is used as an anticonvulsant medication for the treatment of seizures, particularly absence seizures. It functions by stabilizing neuronal membranes and inhibiting the propagation of abnormal electrical activity in the brain, thereby reducing the frequency and severity of seizures.
Used in Neurological Treatments:
Trimethadione is employed as a therapeutic agent in neurological treatments, specifically for managing epilepsy and other seizure disorders. Its effectiveness can be enhanced when used in combination with other anticonvulsant drugs, providing a more comprehensive approach to seizure management.
However, it is important to note that 2,3-Dimethylpyrimidin-4(3H)-one also has the potential for adverse effects, such as drowsiness, dizziness, and gastrointestinal disturbances. Therefore, its use should be carefully monitored and administered under the guidance of a healthcare professional to ensure safety and efficacy.

Upstream product

• 186581-53-3 diazomethane 
• 19875-04-8 2-methyl-3H-pyrimidin-4-one 
• 74-88-4 methyl iodide 
• 53007-48-0 1,2-dimethylpyrimidinium iodide 
• 52698-32-5 1,6-dihydro-1,2-dimethyl-6-iminopyrimidine 
• 78-39-7 Triethyl orthoacetate 
• 109853-38-5 3-exo-amino-N-methylbicyclo<2.2.1>hept-5-ene-2-exo-carboxamide 

Relevant academic research and scientific papers

On the Chichibabin Amination of Pyrimidine and N-Alkylpyrimidinium Salts Using Liquid Ammonia/Potassium Permanganate

Treatment of the 2-R-pyrimidines (1, R = methyl, ethyl, i-propyl and t-butyl) with potassium amide/liquid ammonia/potassium permanganate leads to amination at C-4(6).The yields of the 4(6)-amino compounds 3 increase in the order 2-methyl (10percent), 2-ethyl (30percent), 2-i-propyl (45percent) and 2-t-butyl (60percent).Treatment of the 2-R-N-methylpyrimidinium salts (4, R = hydrogen, methyl) with liquid ammonia/potassium permanganate leads to a regiospecific imination at C-6, the corresponding 2-R-1,6-dihydro-6-imino-1-methylpyrimidines 6 being obtained in 80-85percent yield.It is proved by 15N-labelling that no ring opening is involved in these imination reactions.Treatment of the imino compounds with base leads to the corresponding 2-R-6-methylaminopyrimidines 8, involving, as proved by 15N-labelling, an ANRORC-mechanism. 2-t-Butyl-1-ethylpyrimidinium tetrafluoroborate (9b) when treated with liquid ammonia/potassium permanganate undergoes N-deethylation, 2-t-butylpyrimidine being exclusively formed.

Stereochemical Studies. Part 103. Saturated Heterocycles. Part 107. Preparation of 3-Mono and 2,3-Di-substituted Pyrimidin-4(3H)-ones in Retro-Diels-Alder Reactions. The Correct 1,2-Disubstituted Structure of the Compounds previously described as 2,3-Disu

The orthofomate cyclization of carboxamides (4) obtained from 3-exo-aminobicyclohept-5-ene-2-exo-carboxylic acid (1) yielded intermediate 8,9,10-trinorbornene-fused pyrimidinones (5) and hence 3-substituted pyrimidin-4(3H)-ones (6) through the spli