177583-52-7Relevant academic research and scientific papers
Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor
Lyle, Terry A.,Chen, Zhongguo,Appleby, Sandra D.,Freidinger, Roger M.,Gardell, Stephen J.,Lewis, S. Dale,Li, Ying,Lyle, Elizabeth A.,Lynch Jr., Joseph J.,Mulichak, Anne M.,Ng, Assunta S.,Naylor-Olsen, Adel M.,Sanders, William M.
, p. 67 - 72 (1997)
Removal of the β-ketoamide functionality from L-370,518 (K(i) = 0.09 nM) provided a 5 nM K(i) inhibitor of thrombin: L-371,912. Comparison of the enzyme-inhibitor crystal structures suggests a possible explanation for the relatively small change in affini
