17759-05-6

Basic information

• Product Name: Pyrimidine, 2-methyl-, 1-oxide (8CI,9CI)
• Synonyms: Pyrimidine, 2-methyl-, 1-oxide (8CI,9CI);2-methylpyrimidine 1-oxide
• CAS NO: 17759-05-6
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11394
• Product Categories: PYRIMIDINE
• Mol File: 17759-05-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrimidine, 2-methyl-, 1-oxide (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 2-methyl-, 1-oxide (8CI,9CI)(17759-05-6)
• EPA Substance Registry System: Pyrimidine, 2-methyl-, 1-oxide (8CI,9CI)(17759-05-6)

Safety Data

• Hazardous Substances Data: 17759-05-6(Hazardous Substances Data)

Upstream product

• 5053-43-0 2-methylpyrimidine 

Downstream Products

• 64571-34-2 4-Cyano-2-methylpyrimidin 

Relevant articles and documents

FUSED THIAZOLE DERIVATIVES HAVING AFFINITY FOR THE HISTAMINE H3 RECEPTOR

The present invention relates to novel fused thiazole derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of neurological and psychiatric disorders.

OXIDATION OF 2,4-DISUBSTITUTED PYRIMIDINES WITH ORGANIC PERACIDS

While 4,6-disubstituted (alkyl, aryl, alkoxyl) pyrimidines easily afforded the corresponding mono-N-oxides with hydrogen peroxide in glacial acetic acid, pyrimidine derivatives whose 6-position is free, are partly oxidatively degradated during N-oxidation reaction.The oxidation of the latter compounds under the above conditions gave 2,4-disubstituted imidazoles together with their mono-N-oxides.A likely mechanism of this ring-contraction and the improved conditions for the synthesis of the N-oxides are also described.