177596-48-4Relevant academic research and scientific papers
Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence
Kim, Dong-Ick,Kim, Hak-Yeop,Kwon, Lae-Sung,Park, Sung-Dae,Jeon, Gee-Ho,Jung, Kyung-Yun,Min, Jae-Ki,Nam, Woong-Hyun,Lee, Kiho,Chung, You-Sup,Tanabe, Shigeru,Kozono, Toshiro
, p. 85 - 90 (2007/10/03)
A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence.
