177607-77-1

Basic information

• Product Name: (2S,4S)-2-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
• Synonyms: (2S,4S)-2-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS NO: 177607-77-1
• Molecular Weight: 392.452
• Mol File: 177607-77-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4S)-2-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S)-2-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester(177607-77-1)
• EPA Substance Registry System: (2S,4S)-2-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester(177607-77-1)

Safety Data

• Hazardous Substances Data: 177607-77-1(Hazardous Substances Data)

Upstream product

• 618-27-9 hydroxy L-proline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 17831-01-5 H-Ala-OBzl 
• 87691-27-8 N-tert-butoxycarbonyl-L-cis-4-hydroxyproline 

Downstream Products

• 141205-31-4 microcolin A 
• 177607-78-2 (2S,4S)-2-((S)-1-Benzyloxycarbonyl-ethylcarbamoyl)-4-(tert-butyl-dimethyl-silanyloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Total asymmetric synthesis of the potent immunosuppressive marine natural product microcolin A

The total asymmetric synthesis of the potent immunosuppressive compound microcolin A is reported. The synthesis establishes the absolute stereochemistry of microcolin A as C-36R, C-38R, and C-4S on the basis of the diastereoselective preparation of all four possible diastereomers of the lipid region (fragment A) and diastereoselective synthesis of fragment C starting from natural L-(S)-alanine. The strategy involves a convergent assemblage of three optically pure fragments and is amenable to chemical modifications to examine structural analogs for biological study.