177608-38-7

Upstream product

• 621-84-1 O-benzyl carbamate 
• 177608-41-2 3,5-bis(benzyloxy)-4-methoxystyrene 
• 177608-34-3 (S)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethanol 
• 177608-36-5 (R)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethylamine 
• 501-53-1 benzyl chloroformate 
• 177608-37-6 [(R)-1-(3,5-Bis-benzyloxy-4-methoxy-phenyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid benzyl ester 

Downstream Products

• 219911-59-8 [(1R,2R)-1-{(S)-2-Cyano-1-[(R)-1-(3,5-dihydroxy-4-methoxy-phenyl)-2-hydroxy-ethylcarbamoyl]-ethylcarbamoyl}-2-(4-fluoro-3-nitro-phenyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 
• 331731-43-2 C₅₄H₆₆FN₅O₁₆Si 
• 331731-45-4 [1-({{3-[5-(2-benzyloxy-1-tert-butoxycarbonylamino-ethyl)-2-methoxy-phenoxy]-5-methoxy-phenyl}-[1-(3,5-dihydroxy-4-methoxy-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-carbamoyl)-2-(4-fluoro-3-nitro-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 219911-58-7 5-((R)-1-Amino-2-hydroxy-ethyl)-2-methoxy-benzene-1,3-diol 

Relevant academic research and scientific papers

From styrenes to enantiopure α-arylglycines in two steps

Direct enantioselective synthesis of (R)- and (S)-N-Cbz- or N- BOC-protected α-arylglycinols from styrenes via catalytic asymmetric aminohydroxylation, with enantioselective up to 99% and isolated yields up to 80%, is described. In a subsequent oxidation step, these glycinols yield the corresponding carbamate-protected α-arylglycines.