17766-28-8

Basic information

• Product Name: 1-Cyclohexylpiperazine
• Synonyms: BUTTPARK 82\06-06;N-Cyclohexylpiperazine;1-CYCLOHEXYL-PIPERAZINE >98%;1-CYCLOHEXYLPIPERAZINE 98%;1-Cyclohexylpiperizine;Piperazine, 1-cyclohexyl-;1-Cyclohexylpiperazine ,97%;1-Cyclohexylpiperazine, 98% 25GR
• CAS NO: 17766-28-8
• Molecular Formula: C₁₀H₂₀N₂
• Molecular Weight: 168.28
• EINECS: 241-750-0
• Product Categories: Amines and Anilines;Building Blocks;Heterocyclic Building Blocks;Piperazines
• Mol File: 17766-28-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 28-32 °C
• Boiling Point: 287.25°C (rough estimate)
• Flash Point: 103.3 °C
• Appearance: Yellow-brownish/Low Melting Solid
• Density: 0.9725 (rough estimate)
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.6011
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 9.25±0.10(Predicted)
• BRN: 106845
• CAS DataBase Reference: 1-Cyclohexylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyclohexylpiperazine(17766-28-8)
• EPA Substance Registry System: 1-Cyclohexylpiperazine(17766-28-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-26
• WGK Germany: 3
• Hazardous Substances Data: 17766-28-8(Hazardous Substances Data)

Usage

Chemical Properties

yellow-brownish low melting solid

Uses

1-Cyclohexylpiperazine is an σ1 and σ2 receptor ligands with diagnostic and therapeutic potentials.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 7331, 1994 DOI: 10.1016/0040-4039(94)85306-1

InChI:InChI=1/C10H20N2/c1-2-4-10(5-3-1)12-8-6-11-7-9-12/h10-11H,1-9H2/p+2

Upstream product

• 245487-40-5 cyclohexylpiperazine Hydrochloride 
• 108-85-0 1-bromocyclohexane 
• 159974-46-6 3-(2-Cyclohexylamino-ethyl)-oxazolidin-2-one 
• 110-85-0 piperazine 
• 1224935-95-8 4-cyclohexyl-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 486439-15-0 4-[2-(4-cyclohexyl-piperazin-1-yl)-2-(4-fluoro-phenyl)-ethyl]-piperazine-1-carboxylic acid ethyl ester 
• 1201629-75-5 1-(4-cyclohexyl-piperazin-1-yl)-2-thiophen-2-yl-2-(3-trifluoromethyl-phenylamino)-ethanone 
• 549510-74-9 4-Cyclohexylpiperazine-1-carboxylic acid 4-(4-trifluoromethyl-phenoxy)phenyl ester 
• 570407-42-0 4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolamine 
• 446065-57-2 2-amino-5-(4-cyclohexylpiperazin-1-yl)-4-(4-fluorophenyl)thiazole 
• 112253-44-8 3-Cyclohexyl-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoline-5,5-dicarbonitrile 
• 112253-35-7 2-[2-(4-Cyclohexyl-piperazin-1-yl)-benzylidene]-malononitrile 
• 83546-68-3 [6-(4-Cyclohexyl-piperazin-1-yl)-hexyl]-(6-methoxy-4-methyl-quinolin-8-yl)-amine 
• 766550-10-1 1-[(N-tert-butoxycarbonyl-D-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-4-chloro-D-phenylalanyl]-4-oxy-4-cyclohexylpiperazine 

Relevant articles and documents

Preparation method of 1-cyclohexylpiperazine

The invention discloses a preparation method of 1-cyclohexylpiperazine. The method comprises the steps of carrying out reflux reaction on cyclohexyl halide, 1-Boc-piperazine and inorganic base in an organic solvent, filtering after the reaction is finished, and concentrating to obtain an intermediate 1; removing Boc from the intermediate 1 under an acidic condition, drying by distillation after the reaction is finished, pulping with isopropanol, and filtering to obtain solid 1-cyclohexyl piperazine hydrochloride; dissolving with water, adding an inorganic base to adjust the pH value to 12 to 14, extracting with an extraction solvent, drying the solvent by distillation to obtain a crude product of 1-cyclohexylpiperazine, and carrying out reduced pressure distillation on the crude product through an oil pump to obtain a pure product of 1-cyclohexylpiperazine. In the synthesis process of the intermediate 1, use of sodium triacetoxyborohydride and sodium hydroxide is avoided, the production cost is greatly saved, meanwhile, only filtering is needed for aftertreatment, the method is very simple, and time and labor are saved.

ANALGESIC THAT BINDS FILAMIN A

A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within.