17768-37-5Relevant academic research and scientific papers
Synthese en serie adamantane : preparation d'adamantanes trisubstitues-1,2,3 et -1,2,5 et de protoadamantanones -4 substituees en position -6 ou -8
Drivas, Ioannis,Mison, Pierre
, p. 252 - 264 (2007/10/02)
A regio and diastereospecific synthetic approach to 1,3-dialkyl (and 1,3-diphenyl) adamantanes bearing a functional group in position-2 (7) and to 1,5-dialkyl (and 1,5-diphenyl) 2-adamantanols (syn 8) is described.This has been accomplished through an addition-isomerisation process on two new classes of 4-protoadamantanones bearing a substituent in position 8 or 6 (3 and 4).These have been prepared via an intramolecular base catalysed cyclisation of iodoketones (11), obtained by thermolysis of hypo-iodites (10).
