17773-60-3Relevant academic research and scientific papers
Diverse alkanones by catalytic carbon insertion into the formyl C-H bond. Concise access to the natural precursor of achyrofuran
Wommack, Andrew J.,Moebius, David C.,Travis, Austin L.,Kingsbury, Jason S.
supporting information; experimental part, p. 3202 - 3205 (2009/11/30)
Over a century ago, the first reactions of diazomethane with aldehydes delivered methyl ketones. In the interim, aldehydes have been homologated with trimethylsilyldiazomethane, diazoacetates, and aryldiazomethanes, on rare occasion with catalysis. This work describes a mild procedure for convergent ketone assembly from nonstabilized diazoalkanes, including examples of chiral ketone synthesis with disubstituted (internal) nucleophiles. The method's remarkable tolerance to steric crowding is showcased in a simple approach to achyrofuran, a complex dibenzofuran.
One-pot synthesis of ketones using N-methoxy-N-methyl-2-pyridyl urethane
Lee, Na Ra,Lee, Jae In
, p. 1249 - 1255 (2007/10/03)
The one-pot reaction of N-methoxy-N-methyl-2-pyridyl urethane with Grignard and organolithium reagents provided an efficient method for the preparation of unsymmetrical ketones.
Selective homologation of ketones and aldehydes with diazoalkanes promoted by organoaluminum reagents
Maruoka,Concepcion,Yamamoto
, p. 1283 - 1290 (2007/10/02)
Organoaluminum-promoted single homologation or ring expansion of ketones and aldehydes with diazoalkanes has been described, and among various organoaluminium reagents, exceptionally bulky methylaluminum bis(2,6-di-tert-butyl-4-methylphenoxide) (MAD) is found to be highly effective for the selective homologation of various ketones and aldehydes.
