177735-10-3

Usage

Uses

Used in Pharmaceutical Industry:
(2-methylthiophen-3-yl)boronic acid is used as a reagent for the preparation of functionalized heterocycles, which are essential in the development of antiviral agents. These heterocycles play a crucial role in the design and synthesis of new antiviral drugs, targeting various stages of viral replication and infection processes.
The application of (2-methylthiophen-3-yl)boronic acid in the pharmaceutical industry is primarily due to its ability to facilitate the synthesis of complex heterocycles with potential antiviral properties. These heterocycles can be further modified and optimized to enhance their efficacy and selectivity against specific viral targets, contributing to the development of novel antiviral therapies.

Upstream product

• 30319-05-2 3-bromo-2-methylthiophene 
• 688-74-4 boric acid tributyl ester 
• 910553-12-7 4,4,5,5-tetramethyl-2-(2-methylthiophen-3-yl)-1,3,2-dioxaborolane 

Relevant academic research and scientific papers

Photoinduced Four-State Three-Step Ordering Transformation of Photochromic Terthiophene at a Liquid/Solid Interface Based on Two Principles: Photochromism and Polymorphism

We have investigated photoinduced ordering transformation of a photochromic terthiophene derivative by scanning tunneling microscopy (STM) at the trichlorobenzene (TCB)/highly oriented pyrolytic graphite (HOPG) interface. The open-ring and annulated isomers of the terthiophene formed two-dimensional molecular orderings with different patterns while the closed-ring isomer did not form any ordering. The ordering of the open-ring isomer exhibited polymorphism depending on the concentration of supernatant solution. Upon UV light irradiation to a solution of the open-ring isomer or the closed-ring isomer, ordering composed of the annulated isomer was irreversibly formed. Upon visible light irradiation or thermal stimulus to the closed-ring isomer, the two kinds of polymorph composed of the open-ring isomer were formed due to the polymorphism. By controlling photochromism and polymorphism among four states made of three photochemical isomers, four-state three-step transformation was achieved by in situ photoirradiation from a solution of the closed-ring isomer (no ordering) into the ordering composed of the open-ring isomer (ordering α and β) followed by the orderings composed of the annulated isomer (ordering γ).

Synthetic protocol for diarylethenes through Suzuki-Miyaura coupling

The synthesis of a variety of diarylethenes through the Suzuki-Miyaura coupling reaction of 1,2-dichlorohexafluorocyclopentene with arylboronic acids and esters has been developed. Thiophenes with various substituents such as cyano and ester functionalities can be incorporated.

IMIDAZOPYRIDAZINE COMPOUNDS

The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.