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Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-ethyl-1-methylpiperazine dihydrochloride is used as a chemical intermediate for the synthesis of various pharmaceutical products. Its role in the production process is crucial for creating a range of medications that address different health conditions.
Used in Agricultural Industry:
In the agricultural sector, (2S)-2-ethyl-1-methylpiperazine dihydrochloride is utilized as a precursor in the development of agrochemicals. These agrochemicals are essential for enhancing crop protection and improving overall agricultural productivity.

Upstream product

• 928025-56-3 (S)-3-ethylpiperazin-1-carboxylic acid tert-butyl ester 
• 123-91-1 1,4-dioxane 
• 50-00-0 formaldehyd 
• 438050-08-9 tert-butyl (3R)-3-ethylpiperazine-1-carboxylate 

Relevant academic research and scientific papers

Discovery of Quinazoline-2,4(1 H,3 H)-dione Derivatives Containing 3-Substituted Piperizines as Potent PARP-1/2 Inhibitors-Design, Synthesis, in Vivo Antitumor Activity, and X-ray Crystal Structure Analysis

Inhibiting PARP-1/2 offered an important arsenal for cancer treatments via interfering with DNA repair of cancer cells. Novel PARP-1/2 inhibitors were designed by capitalizing on methyl- or ethyl-substituted piperizine ring to capture the characteristics of adenine-ribose binding site (AD site), and their unique binding features were revealed by the cocrystal structures of compounds 4 and 6 in PARP-1. The investigation on structure-activity relationship resulted in compounds 24 and 32 with high enzymatic potency, binding selectivity, and significantly longer residence time for PARP-1 over PARP-2 (compound 24, PARP-1: IC50 = 0.51 nM, PARP-2: IC50 = 23.11 nM; compound 32, PARP-1: IC50 = 1.31 nM, PARP-2: IC50 = 15.63 nM). Furthermore, compound 24 was determined to be an attractive candidate molecule, which possessed an acceptable pharmacokinetic profile and produced remarkable antitumor activity in both breast cancer xenograft model and glioblastoma orthotopic model in mice, either alone or in combination treatment.

SULFONAMIDE DERIVATIVE HAVING COUMARIN SKELETON

Provided is a novel compound or a salt thereof inhibiting MTHFD2 and useful for treating a disease caused by overexpression of MTHFD2, a disease involved in overexpression of MTHFD2 and/or a disease associated with overexpression of MTHFD2. Solution Provided is a sulfonamide derivative having a coumarin skeleton represented by the following formula (I) and having various substituents: wherein R1, R2, R3, R4, R5, R6 and R7 are the same as defined in the specification, and a salt thereof.

Quinazolinone PARP-1 inhibitors, medicinal composition containing inhibitors, and antitumor use of inhibitors

The invention discloses quinazolinyl-2,4(1H,3H)-dione PARP-1 inhibitors, and a preparation method, a medicinal composition and a use thereof. The invention concretely relates to quinazolinyl-2,4(1H,3H)-dione derivatives represented by general formula I, a medicinal salt and a preparation method thereof, a composition containing one or more of the compounds, and a use of the compounds in the preparation of tumor prevention and/or treatment medicines.