177793-76-9Relevant academic research and scientific papers
Inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates
Lee,Roark,Picard,Sliskovic,Roth,Stanfield,Hamelehle,Bousley,Krause
, p. 289 - 294 (2007/10/03)
Sulfoacetic acid, phosphoramidate, and phosphonamide analogs of the ACAT inhibitors, CI-999 and CI-1011 were synthesized. The structure-activity relationships of these compounds as ACAT inhibitors are described.
Sulfonate ACAT inhibitors
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, (2008/06/13)
β-Carboxy sulfonates of the formula STR1 wherein R1 is aryl, R3 and R4 are hydrogen or alkyl, Y is -O-, -S-, or -NR2 -, and R5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.
