17780-75-5

Basic information

• Product Name: CLORGYLINE HYDROCHLORIDE
• Synonyms: CLORGYLINE HYDROCHLORIDE;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride;N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL
• CAS NO: 17780-75-5
• Molecular Formula: C13H16Cl3NO
• Molecular Weight: 308.63
• EINECS: 241-760-5
• Mol File: 17780-75-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 361.3°Cat760mmHg
• Flash Point: 172.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.1E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
• CAS DataBase Reference: CLORGYLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CLORGYLINE HYDROCHLORIDE(17780-75-5)
• EPA Substance Registry System: CLORGYLINE HYDROCHLORIDE(17780-75-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UI0675000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 17780-75-5(Hazardous Substances Data)

Usage

Description

Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety.

Uses

Different sources of media describe the Uses of 17780-75-5 differently. You can refer to the following data:
1. Antidepressant;Monoamine oxidase A inhibitor
2. N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride has been used as a monoamine oxidase A (MAO-A) inhibitor:in MAO-A biochemical assayto study its effects on the transit of serotonin (5-HT) in the human placenta explantsto study its effects on human prostate cancer cells

Biochem/physiol Actions

MAO-A inhibitor.

references

[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.

InChI:InChI=1/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H