17780-75-5

Basic information

• Product Name: CLORGYLINE HYDROCHLORIDE
• Synonyms: CLORGYLINE HYDROCHLORIDE;N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE;3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride;n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride;N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop;N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride;N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL
• CAS NO: 17780-75-5
• Molecular Formula: C13H16Cl3NO
• Molecular Weight: 308.63
• EINECS: 241-760-5
• Mol File: 17780-75-5.mol

Chemical Properties

• Boiling Point: 361.3°Cat760mmHg
• Flash Point: 172.3°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.1E-05mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: ≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O
• CAS DataBase Reference: CLORGYLINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CLORGYLINE HYDROCHLORIDE(17780-75-5)
• EPA Substance Registry System: CLORGYLINE HYDROCHLORIDE(17780-75-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• RTECS: UI0675000
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 17780-75-5(Hazardous Substances Data)

Usage

Uses

1. Used in Pharmaceutical Industry:
Clorgyline hydrochloride is used as an antidepressant for its ability to inhibit MAO-A, thereby increasing the levels of serotonin in the brain and helping to alleviate symptoms of depression and anxiety.
2. Used in Research and Development:
Clorgyline hydrochloride is used as a monoamine oxidase A (MAO-A) inhibitor in various biochemical assays to study its effects on the transit of serotonin (5-HT) in human placenta explants and its effects on human prostate cancer cells.
3. Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, clorgyline hydrochloride could potentially be used in drug delivery systems to improve its bioavailability and therapeutic outcomes, similar to the application of gallotannin in drug delivery systems.

Biochem/physiol Actions

MAO-A inhibitor.

references

[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10.

InChI:InChI=1/C13H15Cl2NO.ClH/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15;/h1,5-6,10H,4,7-9H2,2H3;1H