17781-31-6

Basic information

• Product Name: alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol
• Synonyms: alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol;EL-241;Parnon;α,α-Bis(4-chlorophenyl)-3-pyridinemethanol
• CAS NO: 17781-31-6
• Molecular Formula: C₁₈H₁₃Cl₂NO
• Molecular Weight: 330.20792
• EINECS: 241-761-0
• Mol File: 17781-31-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 485.3 °C at 760 mmHg
• Flash Point: 247.3 °C
• Appearance: /
• Density: 1.334 g/cm³
• Vapor Pressure: 3.12E-10mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol(17781-31-6)
• EPA Substance Registry System: alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol(17781-31-6)

Safety Data

• Hazardous Substances Data: 17781-31-6(Hazardous Substances Data)

Usage

Description

Alpha,alpha-bis(4-chlorophenyl)pyridine-3-methanol, commonly known as TFM, is a chemical compound that functions as a pesticide and insecticide. It is specifically designed to control and eliminate unwanted fish populations in freshwater ecosystems. TFM operates by disrupting the energy production in the gills of fish, which results in their death. It is often used in conjunction with other chemicals like niclosamide to enhance its effectiveness. TFM has been approved for use by regulatory agencies in various countries and is considered to have low toxicity to non-target organisms when used according to the recommended guidelines. However, it is crucial to handle and use this chemical with care to prevent any adverse environmental effects.

Uses

Used in Pesticide Applications:
TFM is used as a pesticide in the control and elimination of unwanted fish populations in freshwater ecosystems. It is effective due to its ability to disrupt the energy production in the gills of fish, leading to their death.
Used in Insecticide Applications:
TFM also serves as an insecticide, targeting and eliminating insect populations that may be harmful to the ecosystem or human activities.
Used in Combination with Other Chemicals:
TFM is used in combination with other chemicals, such as niclosamide, to increase its effectiveness in controlling and eliminating unwanted fish populations.
Used in Regulatory Compliance:
TFM has been approved for use by regulatory agencies in various countries, ensuring that it meets safety and efficacy standards for controlling fish populations in freshwater ecosystems.
Used in Environmental Management:
TFM is used with care to avoid negative environmental impacts, highlighting its role in responsible environmental management and the need for proper handling and usage to minimize ecological harm.

InChI:InChI=1/C18H13Cl2NO/c19-16-7-3-13(4-8-16)18(22,15-2-1-11-21-12-15)14-5-9-17(20)10-6-14/h1-12,22H

Upstream product

• 626-55-1 3-Bromopyridine 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 106-39-8 bromochlorobenzene 
• 14548-44-8 3-(4-chlorobenzoyl)pyridine 

Downstream Products

• 19828-17-2 α,α-bis(4-chlorophenyl)-α-3-pyridylmethyl methyl ether 
• 5747-90-0 3-(bis(4-chlorophenyl)methyl)pyridine 
• 103022-56-6 3-pyridine 
• 29957-22-0 α-Chloro-α-(3-pyridyl)-4,4'-dichlorodiphenylmethane 
• 19828-08-1 α-chloro-α-3-pyridyl-α-(4,4'-dichlorodiphenyl)methane hydrochloride 
• 117613-40-8 3-pyridine 
• 123124-70-9 3-piperidine 
• 123124-57-2 α,α-bis(4-chlorophenyl)-3-piperidinemethanol 

Relevant articles and documents

Analogues of fenarimol are potent inhibitors of trypanosoma cruzi and are efficacious in a murine model of chagas disease

We report the discovery of nontoxic fungicide fenarimol (1) as an inhibitor of Trypanosoma cruzi (T. cruzi), the causative agent of Chagas disease, and the results of structure-activity investigations leading to potent analogues with low nM IC50s in a T. cruzi whole cell in vitro assay. Lead compounds suppressed blood parasitemia to virtually undetectable levels after once daily oral dosing in mouse models of T. cruzi infection. Compounds are chemically tractable, allowing rapid optimization of target biological activity and drug characteristics. Chemical and biological studies undertaken in the development of the fenarimol series toward the goal of delivering a new drug candidate for Chagas disease are reported.

Method of regulating the growth of aquatic weeds with pyridine derivatives

A method of regulating the growth of submerged and floating aquatic weeds which comprises adding a 3-substituted pyridinemethane, pyridinemethanol, or derivative thereof, to a body of water containing the submerged and floating aquatic weeds to be regulated, in quantities sufficient to regulate the growth of the said submerged and floating aquatic weeds. The disclosure also relates to novel compositions for carrying out the method.