1778219-81-0 Usage
Description
m-PEG3-t-butyl ester is a PEG (polyethylene glycol) linker that incorporates a t-butyl ester group. This molecule features a t-butyl protected carboxyl group, which can be deprotected under acidic conditions. The hydrophilic PEG spacer within the molecule enhances its solubility in aqueous media, making it a versatile compound for various applications.
Uses
Used in Pharmaceutical Industry:
m-PEG3-t-butyl ester is used as a solubility enhancer for improving the aqueous solubility of hydrophobic drugs. The hydrophilic PEG spacer increases the drug's interaction with water, facilitating better dissolution and bioavailability.
Used in Chemical Synthesis:
m-PEG3-t-butyl ester serves as a protecting group for carboxyl functions in chemical synthesis. The t-butyl ester can be selectively deprotected under acidic conditions, allowing for the controlled release of the carboxyl group when needed.
Used in Drug Delivery Systems:
m-PEG3-t-butyl ester is used as a component in the design of drug delivery systems. The PEG linker can be attached to drug molecules or nanoparticles, improving their stability, solubility, and circulation time in the body. Additionally, the t-butyl ester group can be used for controlled release of the drug by deprotection under specific conditions.
Used in Bioconjugation:
m-PEG3-t-butyl ester is utilized as a bioconjugation agent, enabling the attachment of biologically active molecules, such as peptides or proteins, to various surfaces or carriers. The PEG spacer provides a flexible and hydrophilic environment, reducing potential steric hindrance and non-specific interactions.
Used in Diagnostics:
m-PEG3-t-butyl ester can be employed in the development of diagnostic tools, such as imaging agents or sensors, by incorporating the PEG linker into the molecular structure. The hydrophilic nature of the PEG spacer can improve the solubility and biocompatibility of these diagnostic agents, enhancing their performance in biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1778219-81-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,7,7,8,2,1 and 9 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1778219-81:
(9*1)+(8*7)+(7*7)+(6*8)+(5*2)+(4*1)+(3*9)+(2*8)+(1*1)=220
220 % 10 = 0
So 1778219-81-0 is a valid CAS Registry Number.
1778219-81-0Relevant articles and documents
Novel 3-O-pegylated carboxylate and 3-O-pegylated carbamate prodrugs of naltrexone for microneedle-enhanced transdermal delivery
Yerramreddy, Thirupathi Reddy,Milewski, Mikolaj,Penthala, Narsimha Reddy,Stinchcomb, Audra L.,Crooks, Peter A.
scheme or table, p. 3280 - 3283 (2010/08/19)
A small library of novel 3-O-pegylated carboxylate prodrugs (4a-4b) and 3-O-pegylated carbamate prodrugs (9a-9b) of naltrexone were synthesized. The goal behind the design of these prodrugs was to investigate their potential for microneedle-enhanced transdermal delivery. All the synthesized 3-O-pegylated carboxylate prodrugs (4a-4b) and 3-O-pegylated carbamate prodrugs (9a-9b) of naltrexone were found to have adequate stability in a transdermal formulation and improved apparent solubility compared to naltrexone. Viscosity effects were postulated to be responsible for the observed non-linearity in the flux-concentration profile of these prodrugs.
