177840-81-2Relevant academic research and scientific papers
Efficient synthesis of ferrocifens and other ferrocenyl-substituted ethylenes: Via a 'sulfur approach'
Mlostoń, Grzegorz,Hamera-Fa?dyga, Róza,Celeda, Ma?gorzata,Heimgartner, Heinz
, p. 4350 - 4356 (2018/06/21)
Stable and non-odorous alkyl ferrocenyl thioketones react with bis(4-methoxyphenyl)diazomethane according to the 'two-fold extrusion' reaction principles, and tetrasubstituted ethylenes obtained thereby can be demethylated to give (Fc,2OH)-ferrocifens in good yields. The method offers an alternative approach to this class of medically relevant compounds. A similar protocol with alkyl ferrocenyl thioketones and selected diaryldiazomethanes leads to ferrocenyl-substituted ethylenes including dibenzofulvenes. These products are of potential interest for electrochemical and photophysical studies.
Ferrocenyl compounds possessing protected phenol and thiophenol groups: Synthesis, X-ray structure, and in vitro biological effects against breast cancer
Heilmann, Julia B.,Hillard, Elizabeth A.,Plamont, Marie-Aude,Pigeon, Pascal,Bolte, Michael,Jaouen, Gérard,Vessières, Anne
, p. 1716 - 1722 (2008/09/18)
We have previously shown that conjugated ferrocenyl p-phenols show strong cytotoxic effects against both the hormone-dependent MCF-7 and hormone-independent MDA-MB-231 breast cancer cell lines, possibly via metabolic quinone methide (QM) formation. To fur
Ferrocenyl hydroxytamoxifen: A prototype for a new range of oestradiol receptor site-directed cytotoxics
Top, Siden,Tang, Jie,Vessieres, Anne,Carrez, Daniele,Provot, Christian,Jaouen, Gerard
, p. 955 - 956 (2007/10/03)
The synthesis of ferrocenyl hydroxytamoxifen 1, a prototype for a new range of oestradiol receptor site-directed cytotoxic compounds, and some preliminary biochemical tests are reported.
