177845-02-2

Upstream product

• 178032-91-2 3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]furan-2-one 
• 173240-65-8 (4S,5S)-5-((S)-2-Amino-2-methoxycarbonyl-3-phenyl-propyl)-4-benzyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 80343-98-2 3,3a,8,8a-tetrahydro-2H-indeno[2,1-b]furan-2-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 536972-18-6 C₁₉H₂₁NO₂S 
• 536972-19-7 2-((1S,2R)-2-Hydroxy-indan-1-yl)-N-((S)-1-phenyl-ethyl)-acetamide 
• 178032-90-1 (2aR,7aR)-2,2a,7,7a-Tetrahydro-cyclobuta[a]inden-1-one 
• 177845-01-1 [(1S,2R)-2-(tert-Butyl-dimethyl-silanyloxy)-indan-1-yl]-acetaldehyde 
• 31996-70-0 2,2a,7,7a-tetrahydro-cyclobuta[a]inden-1-one 
• 177845-00-0 2-[2-(tert-butyl-dimethyl-silanyloxy)-indan-1-yl]-N-methoxy-N-methyl-acetamide 

Downstream Products

• 177845-03-3 (S)-2-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-2-benzyl-4-((1R,2R)-2-hydroxy-indan-1-yl)-1,2-dihydro-pyrrol-3-one 
• 536972-21-1 (4S,5S)-4-Benzyl-5-[(S)-2-benzyl-4-((1R,2R)-2-hydroxy-indan-1-yl)-3-oxo-2,3-dihydro-1H-pyrrol-2-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 536972-22-2 (4S,5S)-4-Benzyl-5-{(S)-2-benzyl-3-oxo-4-[(1R,2R)-2-(2,2,2-trichloro-acetylcarbamoyloxy)-indan-1-yl]-2,3-dihydro-1H-pyrrol-2-ylmethyl}-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors

The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with i