177846-41-2

Upstream product

• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 177846-36-5 ethyl 2-(4-bromophenylacetyl)-4-methyl-3-oxopentanoate 
• 177846-37-6 5-(4-Bromo-benzyl)-3-isopropyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 
• 143722-25-2 2-(2'-Triphenylmethyl-2'H-tetrazol-5'-yl)-phenylboronic acid 
• 177846-39-8 Ethyl 3-(4-bromophenylmethyl)-5-isopropyl-1-propyl-1H-pyrazole-4-carboxylate 

Relevant academic research and scientific papers

PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONISTS

Compounds of general formula I and their salts and solvates are angiotensin II receptor antagonists and as such are useful in the treatment of hypertension, congestive heart failure and elevated intraocular pressure. Pharmaceutical compositions including these compounds and processes for their preparation are also provided.

Synthesis and structure-activity relationship of a new series of potent AT1 selective angiotensin II receptor antagonists: 5-(biphenyl-4- ylmethyl)pyrazoles

The synthesis and pharmacological activity of a new series of 5- (biphenyl-4-ylmethyl)pyrazoles as potent angiotensin II antagonists both in vitro (binding of [3H]AII) and in vivo (iv, inhibition of AII-induced increase in blood pressure, pithe