177905-46-3

Basic information

• Product Name: Propanamide, 2-hydroxy-N-methoxy-N-methyl-, (2S)-
• CAS NO: 177905-46-3
• Molecular Formula: C5H11NO3
• Molecular Weight: 133.147
• Mol File: 177905-46-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanamide, 2-hydroxy-N-methoxy-N-methyl-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanamide, 2-hydroxy-N-methoxy-N-methyl-, (2S)-(177905-46-3)
• EPA Substance Registry System: Propanamide, 2-hydroxy-N-methoxy-N-methyl-, (2S)-(177905-46-3)

Safety Data

• Hazardous Substances Data: 177905-46-3(Hazardous Substances Data)

Upstream product

• 1760-46-9 diphenylacetic anhydride 
• 117-34-0 2,2-diphenylacetic acid 

Downstream Products

• 152519-33-0 (S)-2-hydroxyhexan-⁽³⁾-one 
• 5650-40-8 (S)-2-hydroxypropiophenone 
• 160666-92-2 (S)-2-benzoyloxypentan-3-one 
• 406940-46-3 (-)-(S)-2-(benzyloxy)-N-methoxy-N-methylpropanamide 

Relevant articles and documents

Kinetic resolution of racemic 2-hydroxyamides using a diphenylacetyl component as an acyl source and a chiral acyl-transfer catalyst

Various optically active 2-hydroxyamide derivatives are produced based on the kinetic resolution of racemic 2-hydroxyamides with a diphenylacetyl component and (R)-benzotetramisole ((R)-BTM), a chiral acyl-transfer catalyst, via asymmetric esterification and acylation. It was revealed that a tertiary amide can be used with this novel protocol to achieve high selectivity (22 examples; s-value reaching over 250). The resulting chiral compounds could be transformed into other useful structures while maintaining their chirality.