17794-28-4 Usage
Uses
Used in Organic Synthesis:
ETHYL (4-AMINOPHENYLAMINO) OXOACETATE is used as a synthetic intermediate for the production of a wide range of organic compounds. Its amino and oxoacetate functional groups make it a suitable candidate for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL (4-AMINOPHENYLAMINO) OXOACETATE is used as a key building block for the development of novel drugs. Its ability to form various complex molecules makes it a valuable asset in the design and synthesis of new therapeutic agents.
Used in Agrochemical Industry:
ETHYL (4-AMINOPHENYLAMINO) OXOACETATE is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its versatility in organic synthesis allows for the development of innovative products to address the ever-changing needs of the agricultural sector.
Used in Dye and Pigment Industry:
In the dye and pigment industry, ETHYL (4-AMINOPHENYLAMINO) OXOACETATE is used as a starting material for the synthesis of various dyes and pigments. Its unique chemical properties enable the creation of a diverse range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Research and Development:
ETHYL (4-AMINOPHENYLAMINO) OXOACETATE is also employed in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its availability as a pale yellow crystalline solid makes it an attractive candidate for use in academic and industrial research settings.
Check Digit Verification of cas no
The CAS Registry Mumber 17794-28-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,9 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 17794-28:
(7*1)+(6*7)+(5*7)+(4*9)+(3*4)+(2*2)+(1*8)=144
144 % 10 = 4
So 17794-28-4 is a valid CAS Registry Number.
17794-28-4Relevant academic research and scientific papers
Zidar, Nace,Toma?i?, Tihomir,Macut, Helena,Sirc, Anja,Brvar, Matja?,Montalv?o, Sofia,Tammela, P?ivi,Ila?, Janez,Kikelj, Danijel
, p. 197 - 211 (2016)
Following the withdrawal of novobiocin, the introduction of a new ATPase inhibitor of DNA gyrase to the clinic would add the first representative of this mechanistic class to the antibacterial pipeline. This would be of great importance because of the well-known problems associated with antibacterial resistance. Using structure-based design and starting from the recently determined crystal structure of the N-phenyl-4,5-dibromopyrrolamide inhibitor-DNA gyrase B complex, we have prepared 28 new N-phenyl-4,5-dibromopyrrolamides and N-phenylindolamides and evaluated them against DNA gyrase from Escherichia coli. The most potent compound was 2-((4-(4,5-dibromo-1H-pyrrole-2-carboxamido)phenyl)amino)-2-oxoacetic acid (9a), with an IC50 of 0.18 μM against E. coli gyrase. A selected set of compounds was evaluated against DNA gyrase from Staphylococcus aureus and against topoisomerase IV from E. coli and S. aureus, but the activities were weaker. The binding affinity of 2-((4-(4,5-dibromo-1H-pyrrole-2-carboxamido)phenyl)amino)-2-oxoacetic acid (9a) to E. coli gyrase was studied using surface plasmon resonance. In the design of the present series, the focus was on the optimisation of biological activities of compounds - especially by varying their size, the position and orientation of key functional groups, and their acid-base properties. The structure-activity relationship (SAR) was examined and the results were rationalised with molecular docking.
