177941-86-5Relevant academic research and scientific papers
N,N'-dialkyldiamide-type phosphate protecting groups for Fmoc synthesis of phosphotyrosine-containing peptides
Ueki, Masaaki,Tachibana, Jun,Ishii, Yusuke,Okumura, Jin,Goto, Mitsutaka
, p. 4953 - 4956 (2007/10/03)
Z-Tyr[P(O)(NHR)2]-OBzl (R=n-Pr and i-Pr) were obtained by reactions of Z-Tyr-OBzl, lithiated with LDA, with N,N -dipropyl- or diisopropyl- phosphorodiamidic chloride. Fmoc derivatives, Fmoc-Tyr][P(O)(NHR)2]-OH, were obtained from them as stable crystals. The P-N bonds are stable toward 20% piperidine in DMF and were cleaved completely with 95% trifluoroacetic acid.
