177947-90-9 Usage
General Description
Acetamide, N-[4-(1-aminoethyl)phenyl]-, (S)- is a chemical compound that belongs to the class of organic compounds known as phenylacetamides. These compounds contain a phenylacetamide moiety, which consists of a phenyl group substituted at the nitrogen atom by an acetamide. The "(S)-" in its name signifies the specific spatial arrangement of its atoms, indicating that it is the 'left-handed' version of this molecule. Acetamide, N-[4-(1-aminoethyl)phenyl]-, (S)- has not been widely studied, so its potential applications and impacts on health or the environment are not well known. Given the presence of nitrogen, hydrogen, and carbon atoms, it is likely that this compound could participate in various chemical reactions and could potentially be used in a variety of industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 177947-90-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,7,9,4 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 177947-90:
(8*1)+(7*7)+(6*7)+(5*9)+(4*4)+(3*7)+(2*9)+(1*0)=199
199 % 10 = 9
So 177947-90-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H14N2O/c1-7(11)9-3-5-10(6-4-9)12-8(2)13/h3-7H,11H2,1-2H3,(H,12,13)/t7-/m0/s1
177947-90-9Relevant articles and documents
3-[3-(piperidin-1-yl)propyl]indoles as highly selective h5-HT(1D) receptor agonists
Russell, Michael G. N.,Matassa, Victor G.,Pengilley, Roy R.,Van Niel, Monique B.,Sohal, Bindi,Watt, Alan P.,Hitzel, Laure,Beer, Margaret S.,Stanton, Josephine A.,Broughton, Howard B.,Castro, José L.
, p. 4981 - 5001 (2007/10/03)
Several 5-HT(ID/1B) receptor agonists are now entering the marketplace as treatments for migraine. This paper describes the development of selective h5-HT(1D)receptor agonists as potential antimigraine agents which may produce fewer side effects. A series of 3-[3-(piperidin-1-yl)propyl]indoles has been synthesized which has led to the identification of 80 (L-772,405), a high- affinity h5-HT(1D) receptor full agonist having 170-fold selectivity for h5- HT(1D) receptors over h5-HT(1B) receptors. L-772,405 also shows very good selectivity over a range of other serotonin and nonserotonin receptors and has excellent bioavailability following subcutaneous administration in rats. It therefore constitutes a valuable tool to delineate the role of h5-HT(1D) receptors in migraine. Molecular modeling and physical properties have been utilized to postulate the binding conformation of these compounds in the receptor cavity.
