177948-63-9

Basic information

• Product Name: Benzyl-Methyl-(S)-1-pyrrolidin-2-ylMethyl-aMine
• Synonyms: Benzyl-Methyl-(S)-1-pyrrolidin-2-ylMethyl-aMine;N-benzyl-N-methyl-1-[(2S)-pyrrolidin-2-yl]methanamine
• CAS NO: 177948-63-9
• Molecular Formula: C₁₃H₂₀N₂
• Molecular Weight: 204.3113
• Mol File: 177948-63-9.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzyl-Methyl-(S)-1-pyrrolidin-2-ylMethyl-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: Benzyl-Methyl-(S)-1-pyrrolidin-2-ylMethyl-aMine(177948-63-9)
• EPA Substance Registry System: Benzyl-Methyl-(S)-1-pyrrolidin-2-ylMethyl-aMine(177948-63-9)

Safety Data

• Hazardous Substances Data: 177948-63-9(Hazardous Substances Data)

Upstream product

• 1217612-28-6 C₁₃H₁₈N₂O 
• 177948-62-8 2-[(benzyl-methyl-amino)-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 69610-40-8 N-(tert-butoxycarbonyl)-L-prolinol 
• 132482-09-8 tert-butyl (2S)-2-{[(methylsulfonyl)oxy]methyl}-pyrrolidine-1-carboxylate 

Downstream Products

• 1026912-47-9 (2S)-4-<3-<(N-benzyl-N-methylamino)methyl>pyrrolidin-1-yl>butanal dimethyl acetal 

Relevant articles and documents

A new chiral synthesis of Wieland-Miescher ketone catalyzed by a combination of (S)-N- benzyl-N(2-pyrrolidinylmethyl)amine derivative and bronsted acid

New or known N-benzyl-N (2-pyrrolidinylmethyl)amine derivatives bearing a variety of substituents on the aromatic ring were easily prepared from N-Boc-proline or NBoc-prolinol. The enantioselectivity of the intramolecular asymmetric aldol reaction mediated by a combination of the amine derivative and Bronsted acid to prepare Wieland-Miescher ketone was examined in detail. During the examination, remarkable substitutional effects on the aromatic ring were observed. Development of a catalytic version of the reaction was successfully achieved by the use of N(9-anthracenyl)methyl-N(2-pyrrolidinyl-methyl)amine in the presence of dichloroacetic acid.