177952-38-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Bis(trifluoromethyl)benzonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to improve the reactivity and stability of the compounds being developed. Its electron-withdrawing properties are particularly beneficial in enhancing the efficacy and selectivity of drug molecules.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-Bis(trifluoromethyl)benzonitrile serves as a crucial building block in the creation of pesticides and other crop protection agents. Its incorporation into these compounds can lead to improved performance and selectivity against pests and diseases.
Used in Organic Synthesis:
As a versatile reagent in organic synthesis, 2,4-Bis(trifluoromethyl)benzonitrile is used to facilitate a range of chemical reactions. Its electron-withdrawing trifluoromethyl groups make it an effective participant in reactions that require enhanced reactivity, such as in the formation of new chemical entities with unique properties.
Used in Material Science:
2,4-Bis(trifluoromethyl)benzonitrile is utilized in the development of new materials with distinct characteristics due to its potent fluorinated aromatic nitrile nature. This makes it suitable for applications where specific material properties are desired, such as in high-performance plastics or advanced coatings.

InChI:InChI=1/C9H3F6N/c10-8(11,12)6-2-1-5(4-16)7(3-6)9(13,14)15/h1-3H

Upstream product

• 7732-18-5 water 
• 140690-56-8 2,4-bis(trifluoromethyl)benzyl bromide 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 
• 77152-08-0 trifluoromethylcopper(I) 
• 100-47-0 benzonitrile 
• 455-18-5 4-CF₃C₆H₄CN 
• 76-05-1 trifluoroacetic acid 
• 101066-87-9 4-iodo-2-(trifluoromethyl)benzonitrile 
• 2314-97-8 iodotrifluoromethane 
• 7440-66-6 zinc 

Downstream Products

• 286010-20-6 2,4-bis(trifluoromethyl)benzylamine 

Relevant academic research and scientific papers

BIS(TRIFLUOROMETHYL)ZINC DMPU COMPLEX, MANUFACTURING METHOD THEREOF AND MANUFACTURING METHOD OF TRIFLUOROMETHYL GROUP-CONTAINING COMPOUND USING THE SAME

PROBLEM TO BE SOLVED: To provide a bis(trifluoromethyl)zinc DMPU complex stable under room temperature and useful as a reaction reagent, a manufacturing method thereof and a manufacturing method of a trifluoromethyl group-containing compound using the same. SOLUTION: A method of obtaining a trifluoromethyl group-containing compound by reacting with a substituted aromatic iodide under a copper (I) catalyst after obtaining a bis(fluoromethyl)zinc DMPU complex represented by the formula (1) (CF3)2Zn (DMPU)2 (1), where DMPU represents N,N'-dimethyl propylene urea, by reacting dialkyl zinc, trifluoromethyl halide and N,N'-dimethyl propylene urea in an organic solvent, then filtration or solvent leaving removal of precipitate. COPYRIGHT: (C)2015,JPOandINPIT

Silver-Catalyzed C-H Trifluoromethylation of Arenes Using Trifluoroacetic Acid as the Trifluoromethylating Reagent

Direct trifluoromethylation of arenes using TFA as the trifluoromethylating reagent was achieved with Ag as the catalyst. This reaction not only provides a new protocol for aryl C-H trifluoromethylation, but the generation of CF3· from TFA may prove useful in other contexts and could potentially be extended to other trifluoromethylation reactions. (Chemical Equation Presented).

Stable but reactive perfluoroalkylzinc reagents: Application in ligand-free copper-catalyzed perfluoroalkylation of aryl iodides

The aromatic perfluoroalkylation catalyzed by a copper(I) salt with bis(perfluoroalkyl)zinc reagents Zn(RF)2(DMPU)2, which were prepared and then isolated as a stable white powder from perfluoroalkyl iodide and diethylzinc, was accomplished to provide the perfluoroalkylated products in good-to-excellent yields. The advantages of this reliable and practical catalytic reaction are 1) airstable and easy-to-handle bis(perfluoroalkyl)zinc reagents can be utilized, 2) the reagent is reactive and hence the operation without activators and ligands is simple, and 3) not only trifluoromethylation but also perfluoroalkylation can be attained.

Trifluoromethylation of arenediazonium salts with fluoroform-derived CuCF3 in aqueous media

A new protocol has been developed for trifluoromethylation of arenediazonium salts with moisture-sensitive CuCF3 (from fluoroform) in aqueous media. The reaction is governed by a radical mechanism, tolerates a broad variety of functional groups, and is applicable to the synthesis of complex, polyfunctionalized molecules. This journal is the Partner Organisations 2014.

Cu-catalyzed trifluoromethylation of aryl iodides with trifluoromethylzinc reagent prepared in situ from trifluoromethyl iodide

The trifluoromethylation of aryl iodides catalyzed by copper(I) salt with trifluoromethylzinc reagent prepared in situ from trifluoromethyl iodide and Zn dust was accomplished. The catalytic reactions proceeded under mild reaction conditions, providing th

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluotomethylbenzylamine represented by the following general formula (1), 1where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4. The process includes hydrogenating a trifluoromethylbenzonitrile by hydrogen in an organic solvent in the presence of ammonia and a catalyst containing a platinum group element. This trifluoromethylbenzonitrile is represented by the following general formula (2), 2where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine at an extremely high yield.

Process for producing trifluoromethylbenzylamines

The invention relates to a process for producing a trifluoromethylbenzylamine represented by the following general formula (1). This process includes hydrogenating a trifliuoromethylbenzonitrile represented by the following general formula (2) by hydrogen in an organic solvent in the presence of ammonia, using a Raney catalyst, where each R independently represents a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine, an alkyl group having a carbon atom number of 1-4, an alkoxy group having a carbon atom number of 1-4, an amino group, a hydroxyl group or a trifluoromethyl group, and n represents an integer from 0 to 4, where R and n are defined as above. With this process, it is possible to obtain the trifluoromethylbenzylamine easily and inexpensively at an extremely high yield.

2,3-dihydro-1-(2,2,2,-trifluoroethyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepines

This invention is concerned with novel compounds represented by structural formula I STR1 where X and Y are independently hydrogen, chloro, fluoro, bromo, iodo, or trifluoromethyl and n is 0, 1 or 2; R is hydrogen, fluoro, chloro, bromo, iodo, or trifluor