177954-77-7

Upstream product

• 23199-54-4 2,3-dihydro-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo[e][1,4]diazepine 
• 36982-84-0 2,4,6-Triisopropylbenzenesulfonyl azide 
• 2898-08-0 2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-one 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 14439-71-5 2'-benzoyl-2-bromo-acetanilide 

Downstream Products

• 177954-79-9 (R)-2-Amino-N-[(R)-2-oxo-5-phenyl-1-(2,2,2-trifluoro-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-3-phenyl-propionamide 
• 177954-81-3 3R-3-Amino-2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepine 
• 177954-78-8 3-amino-5-phenyl-1-(2,2,2-trifluoroethyl)-1H-benzo<1,4>diazepine 

Relevant academic research and scientific papers

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE

The present invention is directed to substituted benozdiazepine compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

An efficient synthesis of 3-amino-1,4-benzodiazepin-2-ones utilizing triisopropylbenzenesulfonyl azide (trisyl azide) for the direct azidation of 1,4-benzodiazepin-2-ones is described.