Calcicludine, a peptide toxin isolated from the venom of the green mamba snake, is a member of the long-chain neurotoxins that specifically target voltage-gated calcium channels. It exhibits a unique mode of action by blocking L-type calcium channels in neurons, which are crucial for neurotransmitter release and synaptic transmission. This blockade results in a reduced release of neurotransmitters like glutamate, impacting neuronal communication and synaptic plasticity. Owing to its distinctive mechanism, calcicludine holds promise for neuroscience research and as a template for developing new therapeutic agents targeting calcium channels.
178037-96-2
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Basic information
- Product Name: CALCICLUDINE
- Synonyms: CALCICLUDINE;CAC;TRP-GLN-PRO-PRO-TRP-TYR-CYS-LYS-GLU-PRO-VAL-ARG-ILE-GLY-SER-CYS-LYS-LYS-GLN -PHE-SER-SER-PHE-TYR-PHE-LYS-TRP-THR-ALA-LYS-LYS-CYS-LEU-PRO-PHE-LEU-PHE-SER-GLY-CYS-GLY-GLY-ASN-ALA-ASN-ARG-PHE-GLN-THR-ILE-GLY-GLU-CYS-ARG-LYS-LYS-CYS -LEU-GLY-LYS;CALCICLUDINE (L-TYPE BLOCKER);Anti-CA2 / CARBONIC ANHYDRASE II antibody produced in rabbit;ANTI-CA2 (N-TERM) antibody produced in rabbit;Carbonate dehydratase II;Carbonic anhydrase 2
- CAS NO:178037-96-2
- Molecular Formula: C319H473 N85 O77 S7
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: −20°C
- Solubility: N/A
- CAS DataBase Reference: CALCICLUDINE(CAS DataBase Reference)
- NIST Chemistry Reference: CALCICLUDINE(178037-96-2)
- EPA Substance Registry System: CALCICLUDINE(178037-96-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 178037-96-2(Hazardous Substances Data)
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178037-96-2 Usage
Uses
Used in Neuroscience Research:Calcicludine is used as a research tool for studying the role of L-type calcium channels in neuronal function and synaptic transmission. Its ability to selectively block these channels provides valuable insights into the mechanisms underlying neurotransmitter release and synaptic plasticity.
Used in Drug Development:
Calcicludine serves as a template for the development of new therapeutic agents targeting calcium channels. Its unique mode of action offers potential applications in the treatment of neurological disorders associated with abnormal calcium channel activity, such as epilepsy, chronic pain, and certain neurodegenerative diseases.
Used in Drug Delivery Systems:
In the pharmaceutical industry, calcicludine can be incorporated into drug delivery systems to enhance its bioavailability, targeting, and therapeutic efficacy. Various carriers, such as nanoparticles or liposomes, can be employed to improve the delivery of calcicludine to specific neuronal populations, ensuring optimal pharmacological effects while minimizing potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 178037-96-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,0,3 and 7 respectively; the second part has 2 digits, 9 and 6 respectively.Calculate Digit Verification of CAS Registry Number 178037-96:
(8*1)+(7*7)+(6*8)+(5*0)+(4*3)+(3*7)+(2*9)+(1*6)=162
162 % 10 = 2
So 178037-96-2 is a valid CAS Registry Number.
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CALCICLUDINE
