17804-59-0

Usage

InChI:InChI=1/C11H20O4/c1-5-14-9(12)7-11(3,4)8-10(13)15-6-2/h5-8H2,1-4H3

Upstream product

• 64-17-5 ethanol 
• 4839-46-7 3,3-Dimethylglutaric acid 
• 21428-65-9 2,2-dibromo-5,5-dimethylcyclohexane-1,3-dione 
• 126-81-8 dimedone 
• 61193-04-2 3-(R,S),5-(R,S)-3,5-dicyano-4,4-dimethyl-2,6-dioxopiperidine 

Downstream Products

• 68427-70-3 3-Hydroxy-5,5-dimethyl-2-o-tolyl-cyclohex-2-enone 
• 83810-33-7 2-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-3,3-dimethyl-pentanedioic acid 1-ethyl ester 
• 83810-32-6 2-[1-(4-Chloro-phenyl)-meth-(Z)-ylidene]-3,3-dimethyl-pentanedioic acid 1-ethyl ester 
• 54008-08-1 1,1,5,5-Tetra-p-chlorphenyl-3,3-dimethylpentan-1,5-diol 
• 106754-11-4 1-benzyl-4,4-dimethylpiperidine-2,6-dione 
• 4839-46-7 3,3-Dimethylglutaric acid 
• 89897-95-0 4,4-dimethylcyclopentane-1,2-dione 
• 37746-17-1 1,5-dibromo-3,3-dimethylpentane 
• 68427-53-2 Ethyl 6-(2', 4'-Dimethylphenyl)-6-cyano-5-keto-3, 3-dimethylhexanoate 
• 53120-74-4 3,3-dimethylpent-1,5-diol 
• 42052-44-8 1,5-diphenyl-3,3-dimethylpentane-1,5-dione 
• 68428-37-5 2-Ethyl-hexanoic acid 2-(2,5-dichloro-4-methyl-phenyl)-5,5-dimethyl-3-oxo-cyclohex-1-enyl ester 
• 68427-55-4 6-(2',4'-Dimethylphenyl)-5-keto-3, 3-dimethylhexanoic acid 
• 54008-10-5 1,1,5,5-Tetrakis-(p-cyanophenyl)-3,3-dimethyl-1,4-pentadien 

Relevant academic research and scientific papers

Geminate-Substituted Cyclopentadienes. 1. Synthesis of 5,5-Dialkylcyclopentadienes via 4,4-Dialkylcyclopent-2-en-1-ones.

A synthetic route for the preparation of 5,5,-dialkylcyclopentadienes (1) via 4,4-dialkylcyclopent-2-en-1-ones (3) is described.Beginnig with ketones (in which the two carbonyl substituents will become the two alkyl groups in the title compounds), the route traverses the Guareschi imides 5, 3,3-dialkylglutaric acids 4 and their ethyl esters 7, masked acyloins 8, cyclopentenones 3, alkohols 9, and bromides 10 to reach the dienes 1.Physical properties of five such derivates 1 and 3 (dimethyl, methylethyl,diethyl, methyl-n-propyl, and methylisopropyl) are presented.

SALT FORM AND CRYSTAL FORM OF 1,2,5-THIADIAZOLIDIN-1,1-DIOXIDE, PREPARATION METHOD THEREOF AND INTERMEDIATE

The present invention discloses a salt form, crystal form and intermediate of the compound 1, and preparation method thereof.

Imidazopyridine or imidazopyrimidine compounds, their production and use

This invention provides a new condensed imidazole compound possessing inhibitory activity of adhesion molecule expression. This invention also provides a therapeutic and prophylactic agent for diabetic nephritis and/or autoimmune disease and an immunosuppressor for organ transplantation.

6- and 4-substituted-1-azabicyclo(3.2.0)heptan-3, 7-dione-2-carboxylates

Disclosed are 6- and 4-substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylic acid esters and salts (I) which are useful in the preparation of 6-, 1- and 2-substituted carbapenem antibiotics. STR1 wherein R5 is a pharmaceutically acceptable ester moiety or a removable protecting group or an alkali or alkaline earth metal cation such as sodium or potassium and wherein R1, R2, Rhu 3 and R4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl and aralkyl. Another embodiment disclosed is a group of compounds having the formula STR2 where X is a leaving group.

184. Stereoselective Hydrolysis of Substituted Cyclopropanedicarboxylates with Pig Liver Esterase

The hydrolysis of the meso-cyclopropane-1,2-dicarboxylates 1a-3a, 4, 5a, 6a, and 9, containing various substituents at C(3), and of the rac-3-phenylcyclopropane-1,2-dicarboxylates 7a, 8a, and 10 with pig liver esterase (PLE) is described.The stereoselectivity and absolute configurations of the products were determined.An interpretation of results was attempted on the basis of a recent active-site model for PLE.

6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids

Disclosed are 1-substituted-6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. STR1 wherein R1 and R2 are, inter alia, substituted and unsubstituted alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl and the spiro substituent formed by the joinder of R1 and R2.

Process for the preparation of carbapenem antibiotics

Disclosed is a process for the synthesis of carbapenem antibiotics I and their pharmaceutically acceptable salts and esters from 1: STR1 wherein: R7, R6, R1, R2 and R8 are selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, spirocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, aralkyl, aralkenyl, aralkynyl, heteroalkyl, heteroaralkyl, heterocyclyl and heterocyclyalkyl.

6- And 1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acid

Disclosed are 6- and 1-substituted-1-carbadethiapen-2-em-3-carboxylic acids I of the following structure: STR1 wherein R1, R2, R3 and R4 are, inter alia, independently selected from the group consisting of alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids

Disclosed are 1-substituted-6-(1-hydroxyethyl)-2-(2-aminoethylthio)-1-carbadethiapen-2-em-3-carboxylic acids (I) and their pharmaceutically acceptable salts and esters which are useful as antibiotics; such compounds are prepared by total synthesis. STR1 wherein R1 and R2 are, inter alia, substituted and unsubstituted alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl and the spiro substituent formed by the joinder of R1 and R2.