1781-70-0Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF NITRO COMPOUNDS AND METHOD FOR THE REMOVAL OF NITROGEN DIOXIDE
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, (2008/06/13)
In the invented process for producing a nitro compound, an organic substrate and nitrogen dioxide are reacted in the presence of oxygen or are reacted in a molar ratio of nitrogen dioxide to the organic substrate of less than 1 to yield a corresponding nitro compound. The reaction may be performed in the presence of N-hydroxyphthalimide or other imide compounds. Such organic substrates include (a) aliphatic hydrocarbons, (b) alicyclic hydrocarbons, (c) non-aromatic heterocyclic compounds each having a carbon atom on a ring, which carbon atom is bonded to a hydrogen atom, (d) compounds each having a carbon-hydrogen bond at the adjacent position to an aromatic ring, and (e) compounds each having a carbon-hydrogen bond at the adjacent position to a carbonyl group. This process can efficiently nitrate an organic substrate even under relatively mild conditions.
S(RN)1 synthesis of new 5-nitroimidazoles highly active against protozoa and anaerobes
Vanelle,Crozet,Maldonado,Barreau
, p. 167 - 178 (2007/10/02)
1-Methyl-2-chloromethyl-5-nitroimidazole reacts by an S(RN)1 mechanism with various aliphatic, cyclic or heterocyclic nitronate anions to afford, in high yields, new 5-nitroimidazoles bearing a trisubstituted ethylenic double bond at the 2 position. Some of these compounds are as active as metronidazole in vitro and in vivo against protozoa and anaerobic bacteria. Structure-activity relationships are discussed.
Synthesis by the S(RN)1 reaction of a new series of imidazo[1,2-a]pyridine derivatives with pharmacological potentialities
Vanelle,Madadi,Roubaud,Maldonado,Crozet
, p. 5173 - 5184 (2007/10/02)
The study of S(RN)1 reaction between 2-chloromethyl-3-nitroimidazo[1,2-a] pyridine and 2-nitropropane salts has been extended to various aliphatic, cyclic and heterocyclic nitronate anions. From C-alkylation products, base-promoted nitrous acid elimination afforded new potential pharmacological derivatives with a trisubstituted double bond at the 2 position.
Oxidative Substitution of Nitroparaffin Salts
Kornblum, Nathan,Singh, Haribansh K.,Kelly, William J.
, p. 332 - 337 (2007/10/02)
α,α-Dinitro compounds, α-nitro sulfones, and α-nitro nitriles are obtained in excellent yields when nitroparaffin salts are coupled to nitrite, benzenesulfinate, and cyanide ions by the agency of potassium ferricyanide.
