178104-96-6

Upstream product

• 17016-83-0 (4S)-4-isopropyl-1,3-oxazolidin-2-one 
• 25026-34-0 4-chlorophenacetyl chloride 

Downstream Products

• 204718-88-7 (2S,3S)-2,3-Bis-(4-chloro-phenyl)-1,4-bis-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-butane-1,4-dione 
• 161745-68-2 (2S,3S)-1,4-Bis-((S)-4-isopropyl-2-oxo-oxazolidin-3-yl)-2,3-diphenyl-butane-1,4-dione 
• 74431-38-2 (2S,3S)-(+)-2,3-Diphenylsuccinic acid 

Relevant academic research and scientific papers

Asymmetric synthesis of optically active 2,3-diarylsuccinic acids by oxidative homocoupling of chiral 3-(arylacetyl)-2-oxazolidones

Oxidative homocoupling of chiral 3-(arylacetyl)-2-oxazolidones 1 was achieved by treatment with DABCO-TiCl4 or DMAP-TiCl4 and afforded the corresponding dimers stereospecifically. The reaction of (4S)- and (4R)-substituted 1 gave (S,S)- and (R,R)-dimers respectively. The obtained dimers were easily transformed to the corresponding 2,3-diaryl succinic acids. This reaction therefore provides a useful method For the synthesis of optically pure 2,3-diarylsuccinic acids. The oxidative coupling was not inhibited by para substitution of an electron donating group on the aryl group. A para-substituted electron withdrawing group and an ortho-substituent, however, hindered the coupling.