178113-64-9

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 178113-57-0 (4S,5R)-5-{(R)-1-[(S)-1-((S)-1-Allyloxycarbonyl-2-methyl-propoxycarbonyl)-ethyl]-octyloxycarbonylmethyl}-4-benzyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 178113-55-8 (4S,5R)-4-Benzyl-5-[(R)-1-((S)-1-benzyloxycarbonyl-ethyl)-octyloxycarbonylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester 
• 178113-53-6 (4S,5R)-3-((2S,3R)-3-hydroxy-2-methyl-1-oxodecanyl)-4-methyl-5-phenyl-2-oxazolidinone 
• 178113-54-7 benzyl (2S,3R)-3-hydroxy-2-methyldecanoate 
• 178113-56-9 L-2-hydroxy-3-methylbutanoic acid allyl ester 
• 158744-40-2 Ethyl 4(S)-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5(R)-oxazolidineacetate 
• 124-13-0 Octanal 

Relevant academic research and scientific papers

Chemical study on hapalosin, a cyclic depsipeptide possessing multidrug resistance reversing activities: Synthesis, structure and biological activity

Hapalosin 1 possessing a multidrug resistance reversing activity, has been synthesized from the corresponding hydroxy acids A, C and γ-amino acid B. The stereochemistry of the natural product 1 and N-demethylhapalosin 11 is discussed by means of spectroscopic manner as well as molecular modeling studies. Biological evaluation of 1 and 11 indicated that a cis-amide function is a crucial factor for the MDR reversing activity.

Synthetic study on hapalosin, a cyclic depsipeptide possessing multidrug resistance reversing activities

Hapalosin possessing a multidrug resistance reversing activity, has been synthesized from the corresponding hydroxy acids and γ-amino acids. The stereochemistry of the natural product and related derivatives is discussed.