178113-67-2Relevant articles and documents
Total synthesis of the multidrug-resistance reversing agent hapalosin
Haddad, Mansour,Botuha, Candice,Larchevêque, Marc
, p. 1118 - 1120 (2007/10/03)
Hapalosin, a new reversing MDR agent, has been synthesized by macrolactamisation of a linear precursor 2 derived from the coupling of a β-hydroxy γ-aminoacid 3 and two hydroxy-esters 4 and 5. The aminoacid 3 was stereoselectively obtained by opening of an anti β-aminoepoxide while the 3-hydroxyacid 4 was prepared by condensation of a lithium compound with (R)-2-phenyl-propanal followed by oxidation of the phenyl group.
Synthetic study on hapalosin, a cyclic depsipeptide possessing multidrug resistance reversing activities
Ohmori, Ken,Okuno, Toshiaki,Nishiyama, Shigeru,Yamamura, Shosuke
, p. 3467 - 3470 (2007/10/03)
Hapalosin possessing a multidrug resistance reversing activity, has been synthesized from the corresponding hydroxy acids and γ-amino acids. The stereochemistry of the natural product and related derivatives is discussed.