178117-16-3

Upstream product

• 178117-14-1 (1R,2S,3R,4S)-2-Benzoylamino-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid methyl ester 
• 155932-76-6 (1R,2S,3R,4S)-3-<(S)-2,2-dimethyl-1,3-dioxolan-4-yl>-bicyclo<2.2.1>-hept-5-en-2-spiro<4'<2'-phenyl-5'(4'H)-oxazolone>> 
• 178117-15-2 (1S,2S,3R,4R)-2-Benzoylamino-3-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-bicyclo[2.2.1]heptane-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues

The title compounds were prepared from key intermediates readily obtained by the stereoselective Diels-Alder reaction of (Z)-2-phenyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethylene]-5(4H)-oxa zolone, a chiral az-lactone derived from (R)-glyceraldehyde and