178169-71-6Relevant academic research and scientific papers
STUDIES ON &α--&β-(4-PHENYLBENZOYL)PROPIONIC ACID AND THE BIOLOGICAL ACTIVITY OF SOME PRODUCTS
Arief, M. M. H.,Essawy, S. A.,Wasfy, A. A. F.,Nassar, S. A.,Hashish, A. A.
, p. 1 - 8 (2007/10/03)
β-(4-phenylbenzoyl)acrylic acid I reacted with 6-(2'-methoxynaphthalenyl)-4-phenylpyrimidine-2(1H)thione to furnish α--β-(4-phenylbenzoyl)propionic acid II.Dehydration of acid II afforded furanone derivative III.The behaviour of III towards hydrazine hydrate, hydroxylamine hydrochloride, primary amines, aromatic hydrocarbons (under Friedel-Crafts conditions) and carbon nucleophiles (under Grignard conditions) has been investigated.Key words: Michael reaction; nitrogen nucleophiles; biological evaluation.
