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Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]-, also known as 5-ethynyl-2'-deoxyuridine (EdU), is a modified nucleoside with a trimethylsilyl group at the 2-position of the ethynyl moiety. It is used in molecular biology for labeling and detection of DNA synthesis, offering high efficiency, low toxicity, and minimal impact on cell proliferation and function.

178179-66-3

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178179-66-3 Usage

Uses

Used in Cell Biology:
Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is used as a DNA labeling agent for visualizing and quantifying proliferating cells during cell replication. The incorporation of EdU into newly synthesized DNA allows for the efficient detection of cell proliferation using click chemistry.
Used in Cancer Research:
In cancer research, Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is employed as a tool for studying tumor growth and identifying cancer stem cells. The ability to label and detect proliferating cells helps in understanding the mechanisms of cancer progression and identifying potential therapeutic targets.
Used in Drug Development:
Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is utilized in drug development for assessing the efficacy of anti-cancer drugs and other therapeutic agents. By labeling and detecting proliferating cells, EdU helps in evaluating the impact of drugs on cell proliferation and identifying potential lead compounds for further development.
Used in Neuroscience Research:
In neuroscience research, Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is applied for studying neurogenesis, the process of generating new neurons from neural stem cells. EdU labeling allows for the visualization and quantification of newly formed neurons, providing insights into the mechanisms of brain development, plasticity, and repair.
Used in Developmental Biology:
Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is employed in developmental biology for studying cell proliferation and differentiation during embryonic development. The ability to label and detect proliferating cells helps in understanding the molecular and cellular processes that drive tissue and organ formation.
Used in Tissue Regeneration and Repair:
In the field of tissue regeneration and repair, Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is used for evaluating the regenerative potential of stem cells and other cell types. EdU labeling enables the assessment of cell proliferation and differentiation in response to injury or disease, providing valuable information for developing regenerative therapies.
Overall, Uridine, 2'-deoxy-5-[(1E)-2-(trimethylsilyl)ethenyl]is a versatile and valuable tool in various scientific disciplines, including cell biology, cancer research, drug development, neuroscience, developmental biology, and tissue regeneration, due to its high efficiency, low toxicity, and minimal impact on cell function.

Check Digit Verification of cas no

The CAS Registry Mumber 178179-66-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,1,7 and 9 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 178179-66:
(8*1)+(7*7)+(6*8)+(5*1)+(4*7)+(3*9)+(2*6)+(1*6)=183
183 % 10 = 3
So 178179-66-3 is a valid CAS Registry Number.

178179-66-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(2-trimethylsilylethenyl)pyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:178179-66-3 SDS

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