178207-67-5Relevant academic research and scientific papers
Preparation of phenolic paclitaxel metabolites
Park, Haeil,Hepperle, Michael,Boge, Thomas C.,Himes, Richard H.,Georg, Gunda I.
, p. 2705 - 2709 (1996)
The synthesis and biological evaluation of the two known phenolic metabolites of paclitaxel are described. The C3'-phenolic metabolite 2 of paclitaxel was prepared from 7-(triethylsilyl)-baccatin III (8) and enantioenriched N-benzoyl-2-azetidinone 7. The C2-phenolic metabolite 3 was synthesized from paclitaxel (1a) via selective C2 debenzoylation and reacylation.
