178208-00-9Relevant academic research and scientific papers
Generation of threonine- and azathreonine N-carboxy anhydrides from α-hydroxy β-lactams promoted by 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) in combination with sodium hypochlorite
Palomo, Claudio,Aizpurua, Jesús M.,Cuevas, Carmen,Urchegui, Raquel,Linden, Anthony
, p. 4400 - 4404 (1996)
A versatile one-pot oxidation-Baeyer-Villiger reaction sequence applied to α-hydroxy β-lactams and promoted by 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO) leads to α-amino acid N-carboxy anhydrides. The examples reported constitute the first application of TEMPO in a Baeyer-Villiger reaction and provide a way for peptide coupling from non α-amino acid precursors.
