178208-18-9

Upstream product

• 26954-85-8 o-homoveratroylhomoveratric acid 
• 20989-17-7 (2S)-2-phenylglycinol 

Downstream Products

• 523-02-4 (S)-(-)-norcoralydine 
• 6901-16-2 (-)-argemonine 
• 4747-98-2 S-(-)-Norlaudanosine 
• 178422-15-6 (S)-2-[(S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-phenyl-ethanol 
• 178208-17-8 (S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 529-79-3 C₂₀H₂₃NO₄ 
• 178357-78-3 (S)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-1,4-dihydro-2H-isoquinolin-3-one 
• 178208-19-0 (S)-1-(3,4-Dimethoxy-benzyl)-2-((S)-2-hydroxy-1-phenyl-ethyl)-6,7-dimethoxy-1,4-dihydro-2H-isoquinolin-3-one 

Relevant academic research and scientific papers

A novel asymmetric route to the 1,3-disubstituted tetrahydroisoquinoline, (-)-argemonine

Chiral bicyclic lactam 13 was converted to the natural product (-)-argemonine 9 in six steps. This novel route to argemonine represents a general strategy for the preparation of chiral 1,3-disubstituted tetrahydroisoquinolines.