178213-19-9

Basic information

• Product Name: benzyl 12-bromododecanoate
• Synonyms: benzyl 12-bromododecanoate
• CAS NO: 178213-19-9
• Molecular Weight: 369.342
• Mol File: 178213-19-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: benzyl 12-bromododecanoate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 12-bromododecanoate(178213-19-9)
• EPA Substance Registry System: benzyl 12-bromododecanoate(178213-19-9)

Safety Data

• Hazardous Substances Data: 178213-19-9(Hazardous Substances Data)

Upstream product

• 73367-80-3 12-bromododecanoic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 178212-95-8 N₄-(benzyl 12'-dodecanoyl)-N₁,N₁₂-bis (tert-butyloxycarbonyl) spermine 
• 936617-31-1 12-{2-[12-(3-Aminooxalyl-4-tert-butoxycarbonylmethoxy-2-methyl-indol-1-yl)-dodecyloxy]-phenoxy}-dodecanoic acid benzyl ester 
• 192213-44-8 N,N'-bis(11-benzyloxycarbonylundecyl)-4,13-diaza-18-crown-6 

Relevant articles and documents

Discovery of Highly Polar β-Homophenylalanine Derivatives as Nonsystemic Intestine-Targeted Dipeptidyl Peptidase IV Inhibitors

Although intensively expressed within intestine, the precise roles of intestinal dipeptidyl peptidase IV (DPPIV) in numerous pathologies remain incompletely understood. Here, we first reported a nonsystemic intestine-targeted (NSIT) DPPIV inhibitor with β-homophenylalanine scaffold, compound 7, which selectively inhibited the intestinal rather than plasmatic DPPIV at an oral dosage as high as 30 mg/kg. We expect that compound 7 could serve as a qualified tissue-selective tool to determine undetected physiological or pathological roles of intestinal DPPIV.

Synthetic ion channel activity documented by electrophysiological methods in living cells

Hydraphiles are synthetic ion channels that use crown ethers as entry portals and that span phospholipid bilayer membranes. Proton and sodium cation transport by these compounds has been demonstrated in liposomes and planar bilayers. In the present work, whole cell patch clamp experiments show that hydraphiles integrate into the membranes of human embryonic kidney (HEK 293) cells and significantly increase membrane conductance. The altered membrane permeability is reversible, and the cells under study remain vital during the experiment. Control compounds that are too short (C8-benzyl channel) to span the bilayer or are inactive owing to a deficiency in the central relay do not induce similar conductance increases. Control experiments confirm that the inactive channel analogues do not show nonspecific effects such as activation of native channels. These studies show that the combination of structural features that have been designed into the hydraphiles afford true, albeit simple, channel function in live cells.