178230-60-9Relevant academic research and scientific papers
Synthesis of sterically fixed podophyllotoxins
Laatsch, Hartmut,Ernst, Bernd Peter,Noltemeyer, Mathias
, p. 731 - 737 (2007/10/03)
Podophyllotoxin and epi-podophyllotoxin derivatives (1/2) with an unsaturated side chain at C-5a were obtained by C-alkylation of protected derivatives of 1. The azide 3a afforded 4 in quantitative yield at 80°C. With pyridine/acetyl chloride, the latter yielded the rigid epi-podophyllotoxin derivative 7, whose structure was established by crystal structure analysis. All reported podophyllotoxin derivatives are less cytotoxic than podophyllotoxin (1a) itself. VCH Verlagsgesellschaft mbH, 1996.
