178307-42-1

Basic information

• Product Name: 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE
• Synonyms: 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE;Revaprazan HCL;5,6-Dimethyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine hydrochloride;Revaprazan hydrochloride;4-(3,4-Dihydro-1-Methyl-2(1H)-isoquinolinyl)-N-(4-fluorophenyl)-5,6-diMethyl-2-pyriMidinaMine Hydrochloride;SB 641257 Hydrochloride;SB 641257A;YH 1885
• CAS NO: 178307-42-1
• Molecular Formula: C22H24ClFN4
• Molecular Weight: 398.9041632
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Inhibitors
• Mol File: 178307-42-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 205-208°
• Boiling Point: 559.3 °C at 760 mmHg
• Flash Point: 292.1 °C
• Appearance: /
• Vapor Pressure: 1.53E-12mmHg at 25°C
• CAS DataBase Reference: 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE(178307-42-1)
• EPA Substance Registry System: 2-PYRIMIDINAMINE, 4-(3,4-DIHYDRO-1-METHYL-2(1H)-ISOQUINOLINYL)-N-(4-FLUOROPHENYL)-5,6-DIMETHYL-, MONOHYDROCHLORIDE(178307-42-1)

Safety Data

• Hazardous Substances Data: 178307-42-1(Hazardous Substances Data)

Usage

Uses

Gastric proton pump inhibitor. Antiulcerative.

InChI:InChI=1/C22H23FN4.ClH/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3;/h4-11,16H,12-13H2,1-3H3,(H,24,25,26);1H

Relevant articles and documents

Revaprazan hydrochloride impurities and preparation method thereof

The invention provides a compound with a structural formula X as shown in the specification, or a tautomer, mesomer, raceme, enantiomer, diastereomer or mixture thereof, or a pharmaceutically acceptable salt or solvate of the compound with the structural

Process for preparation of pyrimidine derivatives

The present invention relates to a process for preparation of 5,6-dimethyl-2-(4-fluorophenyl-amino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine represented by the following formula (I), STR1 and its acid addition salts by reacting a pyrimidi