178309-44-9Relevant academic research and scientific papers
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: Synthesis and inhibitory activity toward phosphodiesterase 5
Watanabe, Nobuhisa,Adachi, Hideyuki,Takase, Yasutaka,Ozaki, Hirofumi,Matsukura, Masayuki,Miyazaki, Kazuki,Ishibashi, Keiji,Ishihara, Hiroki,Kodama, Kohtarou,Nishino, Mayu,Kakiki, Motoharu,Kabasawa, Yasuhiro
, p. 2523 - 2529 (2007/10/03)
We synthesized various 4-(3-chloro-4-methoxybenzyl)aminophthalazines substituted at the 1-and 6-positions and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) and their vasorelaxant activity in isolated porcine coronary arteries preco
Fused pyridazine compounds
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, (2008/06/13)
A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds a
