17833-15-7

Upstream product

• 136-95-8 2-amino-benzthiazole 
• 99-81-0 4-Nitrophenacyl bromide 
• 38956-19-3 2-(2-imino-benzothiazol-3-yl)-1-(4-nitro-phenyl)-ethanone 
• 70-11-1 α-bromoacetophenone 
• 99582-80-6 2-(2-Imino-benzothiazol-3-yl)-1-(4-nitro-phenyl)-ethanone; hydrobromide 
• 17833-07-7 2-phenylimidazo[2,1-b]benzothiazole 

Downstream Products

• 1282523-79-8 4-(imidazo[2,1-b]benzothiazol-2-yl)benzenamine hydrochloride 
• 1276020-75-7 CF₂₀₁ 
• 1276020-69-9 (S)-N-[4-(imidazo[2,1-b]benzothiazol-2-yl)phenyl]-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-hydroxyphenyl)propanamide 
• 1276020-73-5 N-[4-(imidazo[2,1-b]benzothiazol-2-yl)phenyl]-2-[2-(3,5-dimethylphenyl)acetamido]acetamide 
• 1276020-72-4 CF₀₈₂ 
• 1276020-71-3 CF₀₈₁ 
• 1276020-70-2 CF₀₅₂ 
• 1276020-68-8 CF₀₅₆ 
• 1276020-77-9 (S)-N-[4-(imidazo[2,1-b]benzothiazol-2-yl)phenyl]-2-[2-(3,5-bis(trifluoromethyl)phenyl)acetamido]-3-(4-methylphenyl)propanamide 
• 1341192-92-4 C₂₅H₂₂N₄OS 
• 1276020-76-8 (S)-N-[4-(imidazo[2,1-b]benzothiazol-2-yl)phenyl]-2-[2-(3,5-dimethylphenyl)acetamido]-3-(4-methylphenyl)propanamide 
• 1276020-67-7 CF₀₂₂ 
• 950769-48-9 4-(imidazo[2,1-b]benzothiazol-2-yl)benzenamine 

Relevant academic research and scientific papers

On water catalyst-free synthesis of benzo[: D] imidazo[2,1- b] thiazoles and novel N -alkylated 2-aminobenzo [d] oxazoles under microwave irradiation

A highly efficient unprecedented catalyst-free microwave-assisted procedure for synthesizing benzo[d]imidazo[2,1-b]thiazoles and N-alkylated 2-aminobenzo[d]oxazol in green media was developed. The transformation provided rapid access to functionalized ben

Identification of new aminoacid amides containing the imidazo[2,1-b] benzothiazol-2-ylphenyl moiety as inhibitors of tumorigenesis by oncogenic Met signaling

The Met receptor tyrosine kinase is a promising target in anticancer therapies for its role during tumor evolution and resistance to treatment. It is characterized by an unusual structural plasticity as its active site accepts different inhibitor binding

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors

Since activation of p53 in response to cytotoxic stress may have proapoptotic or protective effects depending on the nature of the injury, inhibitors of p53 may have therapeutic interest as modulators of chemotherapy toxicity or efficacy. In an attempt to

NEW AMINOACID DERIVATIVES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES AS INHIBITORS OF ONCOGENIC SIGNALS BY THE MET FAMILY

The present invention concerns novel aminoacids derivatives, in particular some aminoacid amides derivatives, their process of preparation and their use for inhibiting Met-triggered disorders, in particular cancer.

Identification of N-(5-tert-butyl-isoxazol-3-yl)-N′-{4-[7-(2- morpholin-4-yl-ethoxy)imidazo-[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor

Treatment of AML patients with small molecule inhibitors of FLT3 kinase has been explored as a viable therapy. However, these agents are found to be less than optimal for the treatment of AML because of lack of sufficient potency or suboptimal oral pharma

Imidazolothiazole compounds for the treatment of disease

Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.

Imidazobenzothiazoles. 2. New Immunosuppressive Agents

A series of 2-phenylimidazobenzothiazole derivatives was prepared and tested for immunological activities.Some of the compounds showed significant suppressive activity of delayed type hypersensitivity (DTH) without inhibition of humoral immunity in mice by oral administration.The most active compound was 2-(m-hydroxyphenyl)imidazobenzothiazole (20).