178377-98-5Relevant academic research and scientific papers
1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same
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, (2008/06/13)
1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): STR1 where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and A is (CH=CH)m (CH2)n OR, (CH=CH)m (CH2)n NR1 R2, (CH=CH)m (CH2)p B, OH, O(CH2)q OR, O(CH2)q NR1 R2 or O(CH2)r B; q is an integer from 2 to 5; r is an integer from 1 to 2; or the symbol - - - - represents a double bond, A is oxygen, CH(CH=CH)s (CH2)n OR, CH(CH=CH)s (CH2)n NR1 R2 or CH(CH=CH)s (CH2)p B; and L is ?CH=C(R3)!s CH=NR4 or ?CH=C(R3)!s CH2 NHR4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.
1,5-disubstituted 7a-methylperhydroinden-3a-ol derivatives, active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
1,5-disubstituted 7a-methylperhydroinden-3a-ol derivatives having general formula (I): wherein the symbol --------represents a single or a double bond, the symbol represents a Z or E configuration, A and L have the meanings given in the description;, proc
