178378-10-4

Upstream product

• 4747-18-6 O-(2-aminoethyl)hydroxylamine 
• 178379-52-7 (1S,3aS,5S,7aR)-3a-hydroxy-5-phenyl-7a-methylperhydroindene-1-carboxaldehyde 
• 591-51-5 phenyllithium 
• 178379-39-0 (1S,3aS,7aR)-1-hydroxymethyl-3a-hydroxy-7a-methyl-5-perhydroindenone 
• 37866-45-8 2-aminoethoxyamine dihydrochloride 
• 497-19-8 sodium carbonate 
• 392235-04-0 (1S,3aS,5S,7aR)-1-hydroxymethyl-5-phenyl-7a-methylperhydroinden-3a-ol 
• 178379-36-7 (3aS,7aS)-3a-hydroxy-5-spiro-2'-(1',3'-dioxolane)-7a-methyl-1-perhydroindenone 
• 392235-01-7 (1S,3aS,5S,7aR)-1-hydroxymethyl-5-phenyl-7a-methylperhydroinden-3a,5-diol 
• 178379-37-8 (3aS,7aR)-1-methylen-3a-hydroxy-7a-methylperhydroindene-5-spiro-2'-(1',3'-dioxolane) 

Relevant academic research and scientific papers

Synthesis and inotropic activity of 1-(O-aminoalkyloximes) of perhydroindene derivatives as simplified digitalis-like compounds acting on the Na+,K+-ATpase

A series of 5-substituted (3aS,7aR)-7a-methylperhydroinden-3a-o1 derivatives bearing a 1(S)-(ω-aminoalkoxy)iminoalkyl or -alkenyl substituent was synthesized, starting from the Hajos-Parrish ketol 47, as simplified analogues of very potent 17β-aminoalkylo

1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same

1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): STR1 where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and A is (CH=CH)m (CH2)n OR, (CH=CH)m (CH2)n NR1 R2, (CH=CH)m (CH2)p B, OH, O(CH2)q OR, O(CH2)q NR1 R2 or O(CH2)r B; q is an integer from 2 to 5; r is an integer from 1 to 2; or the symbol - - - - represents a double bond, A is oxygen, CH(CH=CH)s (CH2)n OR, CH(CH=CH)s (CH2)n NR1 R2 or CH(CH=CH)s (CH2)p B; and L is ?CH=C(R3)!s CH=NR4 or ?CH=C(R3)!s CH2 NHR4, in the E configuration, are useful for treating cardiovascular disorders such as heart failure and hypertension.

1,5-disubstituted 7a-methylperhydroinden-3a-ol derivatives, active on the cardiovascular system, processes for their preparation and pharmaceutical compositions containing them

1,5-disubstituted 7a-methylperhydroinden-3a-ol derivatives having general formula (I): wherein the symbol --------represents a single or a double bond, the symbol represents a Z or E configuration, A and L have the meanings given in the description;, proc