178390-38-0Relevant academic research and scientific papers
Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines
Zhang, Yonghui,Leon, Annette,Song, Yongcheng,Studer, Danielle,Haase, Christa,Koscielski, Lukasz A.,Oldfield, Eric
, p. 5804 - 5814 (2007/10/03)
We synthesized and tested three series of bisphosphonates for their activity in inhibiting the growth of three human tumor cell lines: MCF-7 (breast), NCI-H460 (lung), and SF-268 (CNS). The first series of compounds consisted of 49 nitrogen-containing bis
A versatile Synthesis of Carboxypyridine Betaines and their 1H and 13C NMR Spectra
Dega-Szafran, Zofia,Kowalczyk, Iwona,Szafran, Miroslaw
, p. 303 - 312 (2007/10/03)
Pyridine betaine and 15 substituted pyridine betaines were prepared by alkylation of R-pyridines with ethyl chloroacetate.The ester group was removed by acid hydrolysis and the obtained hydrochlorides were left with propylene oxide in order to obtain pure, free R-pyridine betaines.The 1H and 13C NMR spectra of free betaines and their hydrochlorides were analysed with respect to an interaction of the ring substituents with N+CH2COO group. - Key words: R-pyridine betaines; ethyl chloroacetate; propylene oxide; IR spectra; 1H and 13C NMR spectra.
