178415-63-9Relevant academic research and scientific papers
Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid
Valli, Matthew J.,Schoepp, Darryle D.,Wright, Rebecca A.,Johnson, Bryan G.,Kingston, Ann E.,Tomlinson, Rosemarie,Monn, James A.
, p. 1985 - 1990 (2007/10/03)
A series of N1-substituted derivatives of (2R,4R)-4-aminopyrrolidine- 2,4-dicarboxylate (2R,4R-APDC) has been prepared as constrained analogs of γ-substituted glutamic acids and examined for their effects at recombinant metabotropic glutamate receptor (mGluR) subtypes in vitro. Appropriate substitution of the N1 position of 2R,4R-APDC resulted in the identification of a number of selective group II mGluR antagonists.
Pyrrolidinyl di-carboxylic acid derivatives as metabotropic glutamate receptor antagonists
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, (2008/06/13)
The present invention provides pyrrolidinyl di-carboxylic acid derivatives that affect certain excitatory amino acid receptors, and are useful in the treatment of neurological disorders and psychiatric disorders. This invention further provides novel pyrr
